Drug Distribution in the Body

After absorption, drugs enter the bloodstream and are distributed throughout the body, a process known as drug distribution. The distribution of a drug is influenced by various factors, including blood flow to different tissues, the drug's affinity for binding proteins, and the permeability of cellular membranes. Highly perfused tissues such as the liver, heart, and kidneys receive drugs more rapidly than less perfused tissues, affecting the rate and extent of drug distribution. Additionally, drugs can bind to plasma proteins, such as albumin, which can impact their distribution and availability at the site of action. Distribution is critical in determining the effective concentration of a drug at its target site and influences factors like drug half-life and dosing intervals. Understanding drug distribution patterns is essential in optimizing drug therapy and minimizing the risk of adverse effects.